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Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration.

Veröffentlicht in: The Journal of pharmacology and experimental therapeutics

Veröffentlicht im: Aug 1947

[Evaluation of changes in hemodynamic parameters after the use of electronic nicotine delivery systems among regular cigarette smokers].


A relatively new device, described by producers as a device to help smokers quit, nicotine inhaler is an electronic (e-cigarette). Its mission is to provide the body with small doses of nicotine behavior "ceremonial" burning product is not tested for efficacy and toxicity The aim of this study was to compare the effects of nicotine absorbed from cigarette conventional and electronic changes in systolic and diastolic blood pressure and heart rate. Because of the potential interaction of carbon monoxide contained in cigarette smoke and nicotine conventional to changes on the parameters is also going to examine changes in the concentration of carboxyhemoglobin after smoking cigarettes and using e-cigarettes. study group consisted of 42 people, including 21 women and 21 men aged from 18 to 62 years who declared daily cigarette smoking. In this study it was found that as a result of cigarette smoking are increasing all the analyzed conventional hemodynamic parameters, these increases probably normally associated with nicotine absorbed by the smoker with the smoke. It was also a clear increase in carboxyhemoglobin, which is associated with a high concentration of carbon monoxide in cigarette smoke. If you use the e-cigarettes tested were observed increases in diastolic blood pressure and pulse, but none of the parameters did not change significantly, indicating that either the use of e-cigarette by the respondents did not supply the body with absorbable nicotine or for the increase in haemodynamic parameters studied did not correspond only nicotine but also other smoke constituents that interact with nicotine to the smoker body as carbon monoxide.

Veröffentlicht in: Przegla¸d lekarski

Veröffentlicht im: Jan 1970

Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study.


Cigarette smoking is a tough addiction to break. Therefore, improved approaches to smoking cessation are necessary. The electronic-cigarette (e-Cigarette), a battery-powered electronic nicotine delivery device (ENDD) resembling a cigarette, may help smokers to remain abstinent during their quit attempt or to reduce cigarette consumption. Efficacy and safety of these devices in long-term smoking cessation and/or smoking reduction studies have never been investigated.

Veröffentlicht in: BMC public health

Veröffentlicht im: Jan 1970

Electronic cigarettes and thirdhand tobacco smoke: two emerging health care challenges for the primary care provider.


PRIMARY CARE PROVIDERS SHOULD BE AWARE OF TWO NEW DEVELOPMENTS IN NICOTINE ADDICTION AND SMOKING CESSATION: 1) the emergence of a novel nicotine delivery system known as the electronic (e-) cigarette; and 2) new reports of residual environmental nicotine and other biopersistent toxicants found in cigarette smoke, recently described as "thirdhand smoke". The purpose of this article is to provide a clinician-friendly introduction to these two emerging issues so that clinicians are well prepared to counsel smokers about newly recognized health concerns relevant to tobacco use. E-cigarettes are battery powered devices that convert nicotine into a vapor that can be inhaled. The World Health Organization has termed these devices electronic nicotine delivery systems (ENDS). The vapors from ENDS are complex mixtures of chemicals, not pure nicotine. It is unknown whether inhalation of the complex mixture of chemicals found in ENDS vapors is safe. There is no evidence that e-cigarettes are effective treatment for nicotine addiction. ENDS are not approved as smoking cessation devices. Primary care givers should anticipate being questioned by patients about the advisability of using e-cigarettes as a smoking cessation device. The term thirdhand smoke first appeared in the medical literature in 2009 when investigators introduced the term to describe residual tobacco smoke contamination that remains after the cigarette is extinguished. Thirdhand smoke is a hazardous exposure resulting from cigarette smoke residue that accumulates in cars, homes, and other indoor spaces. Tobacco-derived toxicants can react to form potent cancer causing compounds. Exposure to thirdhand smoke can occur through the skin, by breathing, and by ingestion long after smoke has cleared from a room. Counseling patients about the hazards of thirdhand smoke may provide additional motivation to quit smoking.

Veröffentlicht in: International journal of general medicine

Veröffentlicht im: Jan 1970

[Recommendations of the World Health Organization Tobacco Control Research Team regarding electronic nicotine delivery devices].


Negative health, social and economic consequences of smoking tobacco are widely known. Recent years have seen the emergence of many commercially sold appliances for inducing nicotine into the airways, including products such as "e-cigarette", "E-cigar" and "green cigarette". These products are often promoted as potential alternatives to nicotine replacement therapy. It transpires, however, that there is a lack of conclusive evidence concerning the health effects of long-term use of chemical substances applied via those electronic nicotine inhalers. Reliable data on the exact chemical composition of the cartridges used in the inhalers is also missing. The objective was to present the main conclusions and recommendations of the World Health Organization Tobacco Control Research Team regarding electronic nicotine delivery devices, which were formulated against the principles of the WHO Framework Convention on Tobacco Control (FCTC). Based on several analyses, WHO recommends a ban on disseminating information that suggest that electronic nicotine vaporisers are safer than cigarettes, or that they are an effective way of combating nicotine addition, until appropriate evidence can be provided. According to the WHO recommendations, references to efficacy of electronic vaporisers for quitting smoking or to their health effects must be backed by reliable pharmacokinetics studies, safety and efficacy tests and appropriate certification from regulatory bodies.

Veröffentlicht in: Przegla¸d lekarski

Veröffentlicht im: Jan 1970



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